NFL Picks Week 5: Cardinals vs 49ers

This is a picture of the Arizona Cardinals vs San Francisco 49ers for the NFL Picks week 5 article preview

The San Francisco 49ers and the Arizona Cardinals are set to face off this Sunday at Levi’s Stadium. Even though the Cardinals are hosting the game, the 49ers are still considered the clear favorites to win. Which team will you be supporting? In this NFL Picks Week 5: Cardinals vs 49ers article, I’ll tell you all the information you need to know about this game.  If you want to place bets on the game check out our sports betting page. (non-Ontario).

Arizona Cardinals vs San Francisco 49ers (Sunday, Oct 6th)

The Arizona Cardinals enter this matchup after a tough 42-14 loss to the Washington Commanders. In that game, Kyler Murray threw for 142 passing yards and 1 touchdown, while James Conner and Marvin Harrison Jr. each added a touchdown. While the Cardinals are playing slightly better than last season, they still have defensive issues that need to be addressed. They currently sit in third place in the NFC West with a record of 1 win and 3 losses.
On the other hand, the San Francisco 49ers are having a stronger season than the Cardinals, holding second place in the NFC West with a 2-2 record. They are coming off an impressive 30-13 win over the New England Patriots, with Brock Purdy throwing for 288 yards and 1 touchdown.
If I had to predict this game, I would pick the 49ers to come out on top. Although the Cardinals will be playing at home, I don’t see them overcoming such a strong team like the 49ers. These two teams last met in December 2023, with the 49ers winning 45-29.

My pick: The San Francisco 49ers to win this game.

SportsbookArizona Cardinals Moneyline OddsSan Francisco 49ers Moneyline Odds
iBet+286-357
PowerPlay Sports+275-345
BetOBet+277-370
Odds were correct at the time of writing. Please check the specific site for the most up-to-date odds.

Point Spread Odds

Online Sports Betting SiteArizona Cardinals OddsSan Francisco 49ers Odds
iBet(-114) +7.5(-104) -7.5
PowerPlay Sports(-120) +7.5(-110) -7.5
BetOBet(-119) +7.5(-108) -7.5
Odds were correct at the time of writing. Please check the specific site for the most up-to-date odds.
This is a picture of the 49ers against the Cardinals for the NFL Picks week 5 article preview
Arizona Cardinals vs San Francisco 49ers

Arizona Cardinals Injury Report

  • Khyiris Tonga
  • Trey McBride
  • Justin Jones

San Francisco 49ers Injury Report

  • Fred Warner
  • Talanoa Hufanga
  • Chris Conley
  • Jordan Elliott

This ends my NFL Picks Week 5: Cardinals vs 49ers article. What are your thoughts on that? Have a look at our online sportsbooks reviews If you want to learn more about the NFL’s greatest betting odds. Check DAZN Canada in order for you to view all the games you want.

About the Author

João Pedro Freitas

João Pedro Freitas has been working in online gambling since 2022, being the most recent addition to the team. He loves to write sports articles and likes to analyse all kinds of sports, especially soccer and UFC. João focuses on writing content and creating strategies to ensure that the team is up to date on all Canadian and American sports.
LinkedIn